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1P-LSD also known as 1-propionyl-LSD and 1-propionyl-lysergic acid diethylamide, is the 1-propionyl analog of LSD.

IUPAC: 1-propionyl-lysergic acid diethylamide

CAS#: N/A

Molecular Mass: 379.45926g/mol

Molecular Formula: C23H29N3O2

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1p-LSD, short for 1 Propionyl Lysergic Acid Diethylamide is the hallucinogenic, psychedelic drug that belongs to the family of lysergamide.

Surprisingly it is structurally similar to LSD and ALD 52 which suggests it has an identical effect profile as well. With the lack of research related to this substance, every argument related to the pharmacology of this drug is completely according to its structure and the subjective effect that are not different from other such lysergamides.

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According to its molecular structure, it belongs to the lysergamide family. It is quite analogous to LSD, and it has been named for its propionyl group that is bound to the nitrogen of the polycyclic indole group. The propionyl consists of a carbonyl chain that is bound to an amino group. 1p-LSD contains a polycyclic group that features the bicyclic Hexahydro indole bound to its quinolone bicyclic group. At carbon 9 of quinoline, the n-diethyl carboxamide becomes bound.

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It acts as the partial agonist of 5 HT2A. Psychedelic effects come from efficacy at 5HT2A receptors. The role of such interactions and how these result in psychedelic experience always remain elusive.

Moreover, it has been theorized that 1p-LSD is a prodrug to LS. It shows only 35% potency of LDS in mice. The LSD is detected with the help of LC-MS when the 1p-LSD is incubated in Human Serum. This means that 1p-LSD doesn’t only act as a prodrug for LSD but also, it directly acts as a serotonin receptor against its very own rights.

1P-LSD Subjective Effects

The subjective effects of 1p-LSD are similar to those structurally related to it. The differences are minuscule that is negligible and virtually indistinguishable from each other. As compared to other psychedelics which include LS and Psilocin, the 1p-LSD proves to be even more stimulating and fast-paced when it comes to a specific type of its physical and cognitive effects. The effects are listed below that is based on the subjective effects index and personal experience of some subjects. The listed effects rarely occur and only once. However if the dosage is heavy, it can lead to severe cases.

Physical Effects

Tactile Sensations

Stimulation

Bodily controlled enhancement

Nausea

Tactile improved

Pupil Dilation

Increase heart rate

Cognitive Effects

Current mind state enhancement

Thought acceleration

Novelty enhancement

Immersion enhancement

Time distortion

Ego death

Mindfulness

Thought loops

Delusions

Feeling interdependent opposites

Conceptual thinking

Self-design feeling

Wakefulness

Creativity enhancement

Though disorganization

Spiritual enhancement

Personal bias enhancement

Auditory Effects

Distortions

Hallucination

Enhancement

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